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Actos Side Effects

Actos can result in serious injuries such as heart attacks and heart failure. In fact, a recent study shows the heart risk from Actos is as great as Avandia. The study evaluated more than 28,000 clients who took either Avandia or Actos from 2001-2005. The study reported that about 4 percent of each group had a heart attack, heart failure, or died.

Ninety-six patients on Avandia suffered a heart attack, compared with 121 on Actos. In addition, 243 Actos patients suffered heart failure, and 18 Actos users suffered both heart attack and heart failure. Finally, 217 patients taking Actos died.

actos Heart Attacks and Heart Failure

Heart failure and heart attacks occur when blood flow to a section of heart muscle becomes blocked. If the flow of blood isn't restored quickly, the section of heart muscle becomes damaged from lack of oxygen and begins to die. The most common heart attack signs and symptoms are:

  • Chest discomfort or pain—uncomfortable pressure, squeezing, fullness, or pain in the center of the chest that can be mild or strong.
  • Upper body discomfort in one or both arms, the back, neck, jaw, or stomach.
  • Shortness of breath may occur with or before chest discomfort.
  • Other signs include nausea, vomiting, lightheadedness, fainting, or breaking out in a cold sweat.

Bladder Tumors

A French study earlier this year showed that Actos carried an increased risk of bladder cancer. In response, France withdrew the drug from the market. In addition, Germany recently discouraged physicians from prescribing the drug, citing the risk of bladder tumors.

Other Side Effects of Actos

Additional side effects from Actos include shortness of breath; swelling or rapid weight gain; chest pain or heavy feeling; nausea; stomach pain; loss of appetite; dark urine; clay-colored stools; jaundice (yellowing of the skin or eyes); blurred vision; increased thirst or hunger; urinating more than usual; pale skin; easy bruising or bleeding; and weakness.


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